- Uses
- Warnings
- Side Effects
- Dosage
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
-
Comments
-
**COMMENTSTAGLIST**
-
More
-
**OTHERTAGLIST**
Brand Name: Lyrica
Generic Name: pregabalin
Drug Class: Fibromyalgia Agents, Anticonvulsants, Other
What is Lyrica, and what is it used for?
Lyrica (pregabalin) is an oral medication that is chemically related to gabapentin (Gralise, Neurontin). It is used for treating pain caused by neurologic diseases such as postherpetic neuralgia as well as seizures. It also is used for treating fibromyalgia.
Lyrica is used for:
- Neuropathic pain associated with diabetic peripheral neuropathy or postherpetic neuralgia
- Spinal cord injury
- In combination with other drugs to treat partial onset seizures in adults
- Treating fibromyalgia
Warnings
Antiepileptic medications have been associated with increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
What are the side effects of Lyrica?
The most common side effects of Lyrica are
- dizziness,
- drowsiness,
- dry mouth (xerostomia),
- edema (accumulation of fluid),
- blurred vision,
- double vision (diplopia),
- weight gain,
- fatigue (tiredness),
- abnormal gait (ataxia),
- tremor, and
- difficulty concentrating.
Other side effects include
- constipation,
- increased appetite,
- nausea,
- flatulence,
- amnesia,
- disorientation,
- myoclonus (sudden, involuntary jerking of a muscle or muscle groups),
- heart failure,
- low blood pressure,
- vomiting,
- reduced blood platelet counts, and
- increased blood creatinine kinase levels.
Increased creatinine kinase can be a sign of muscle injury, and in clinical trials three patients experienced rhabdomyolysis (severe muscle injury). Therefore, patients should report unexplained muscle pain, tenderness or weakness to their doctors, especially if associated with fever and malaise (reduced well-being). Lyrica has rarely been associated with angioedema (swelling of the face, tongue, lips, and gums, throat and larynx).
SLIDESHOW
See SlideshowWhat is the dosage for Lyrica?
- Lyrica may be taken with or without food.
- Treating diabetic peripheral neuropathy: The initial dose for neuropathic pain associated with diabetic peripheral neuropathy is 50 mg three times a day (150 mg/day). The dose may be increased to a maximum dose of 100 mg 3 times daily (300 mg/day) after one week.
- Treating postherpetic neuralgia: The recommended dose for postherpetic neuralgia is 75-150 mg twice daily or 50-100 mg three times daily. Dosing should begin at 75 mg two times a day or 50 mg three times a day (150 mg/day). The dose may be increased to 100 mg 3 times daily (300 mg/day) after one week. If pain relief is inadequate after 2-4 weeks of treatment at 300 mg/day, the dose may be increased to 300 mg twice daily or 200 mg three times daily. Doses greater than 300 mg cause more side effects.
- Treating neuropathic pain associated with spinal cord injury: The dose for treating neuropathic pain associated with spinal cord injury is 150 to 600 mg daily. Begin dosing at 75 mg two times a day an increase to 150 mg two times daily after one week if response is inadequate. May increase to 300 mg twice daily if response is inadequate after 2 to 3 weeks.
- Treating seizures: The recommended dose for treating seizures is 150-600 mg/day divided into 2 or 3 doses, starting at 150 mg daily and increasing based on response and tolerability. The maximum dose is 600 mg/day.
- Treating fibromyalgia: Fibromyalgia is treated with 300-450 mg/day in 2 or 3 divided doses.
Which drugs interact with Lyrica?
- Alcohol and drugs that cause sedation may increase the sedative effects of pregabalin.
- Pioglitazone (Actos) and rosiglitazone (Avandia) cause weight gain, fluid retention, and possibly heart failure. Therefore, combining pregabalin with these drugs may increase the occurrence of weight gain and fluid retention.
Health News
- Kids With Common Skin Conditions Face Stigma, Bullying
- 'Dream It, Be It?' Study Finds Teens Who Focus on Life Goals Often Succeed
- There's an 'Epidemic' of Loneliness Among U.S. Parents, Poll Finds
- Cancer Takes Tough Toll on Family Finances
- New Rules Mean 3.6 Million Americans Could Get Wegovy Via Medicare, Costing Billions
- More Health News ยป
Is Lyrica safe to use during pregnancy or while breastfeeding?
- There are no adequate studies of Lyrica in pregnant women.
- It is not known whether Lyrica is excreted in breast milk.
What else should I know about Lyrica?
Do I need a prescription for Lyrica?
- Yes.
What preparations of Lyrica are available?
- Capsules: 25, 50, 75, 100, 150, 200, 225, and 300 mg.
- Oral Solution: 20 mg/ml
How should I keep Lyrica stored?
- Pregabalin should be stored at room temperature, from 15 C to 30 C (59 F to 86 F).
How does Lyrica work?
- The mechanism of action of pregabalin is unknown. Pregabalin binds to calcium channels on nerves and may modify the release of neurotransmitters (chemicals that nerves use to communicate with each other). Reducing communication between nerves may contribute to pregabalin's effect on pain and seizures.
When was Lyrica approved by the FDA?
- The FDA approved pregabalin in December 2004.
Summary
Lyrica is a drug prescribed for the treatment of neuropathic pain associated with diabetic peripheral neuropathy or post neuralgia; partial onset seizures in adults; and fibromyalgia. Side effects include blurred vision, double vision (diplopia), weight gain, fatigue (tiredness), constipation, increased appetite, nausea, and intestinal gas.
Multimedia: Slideshows, Images & Quizzes
-
Diabetes Nerve Pain: Improving Diabetic Peripheral Neuropathy
Learn how to cope with the symptoms of diabetic peripheral neuropathy through pain management exercises. Find relief for diabetic...
-
Pain Management: 15 Easy Ways to Reduce Chronic Pain
Chronic pain can be a symptom of many conditions, including arthritis, headaches, and others. Comprehensive chronic pain...
-
Nerve Pain: Symptoms, Causes, and Treatment Options
Learn about nerve pain symptoms, causes, and treatment options. Discover medications and natural remedies to relieve nerve pain.
-
Chronic Pain Syndrome: Treatment and Management for CPS
Do you suffer from excruciating pain? What is chronic pain syndrome (CPS)? See causes, symptoms and treatment options, including...
-
Diabetic Neuropathy Quiz: Test Your Medical IQ
Diabetic neuropathy is serious. Take this quiz to get the facts.
-
Epilepsy & Seizures Quiz: What Causes Seizures?
Do you know the difference between seizures and epilepsy? What are the types of seizures? Take the Epilepsy & Seizures Quiz to...
-
Fibromyalgia Quiz: What Is Fibromyalgia?
Fibromyalgia could be the reason for your constant, deep bodily pain. Learn more about this painful condition with the...
-
Chronic Fatigue Syndrome Quiz: Symptoms & Treatment
Exhausted all the time? Maybe it's not all in the mind. Take the Chronic Fatigue Syndrome (CFS) Quiz to learn more about tricky...
-
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
-
Fibromyalgia Relief: Treatments and Tips to Ease Pain and Other Symptoms
What is fibromyalgia? Learn about fibromyalgia symptoms such as trigger points (also called tender points), learn what causes...
-
Picture of Fibromyalgia
A syndrome characterized by chronic pain, stiffness, and tenderness of muscles, tendons, and joints without detectable...
-
How Does Acupuncture Work? Benefits, Needles, Definition
What is acupuncture? How does acupuncture work? Does acupuncture hurt? Learn various acupuncture points, the definition of...
-
Fibromyalgia Pain Relief: Stretching and Strength Exercises
Living with fibromyalgia is painful. By making simple exercise modifications, you can boost your energy, decrease pain and...
-
What Is Fibromyalgia (Fibro)? Symptoms, Causes, Helpful Treatments
What is fibromyalgia? Learn the possible causes of fibro, along with standard and alternative treatments for this chronic...
-
Diabetes: Diabetic Peripheral Neuropathy Treatment
This nerve damage is a common complication of both type 1 and type 2 diabetes. Find out how to prevent it, slow its progression,...
-
Diabetes: Guide to Diabetic Peripheral Neuropathy
Diabetes can damage the nerves that help you feel pain, heat, and cold, especially in your feet. Learn about the symptoms of...
-
Fibromyalgia: Easy Home Exercises to Manage Fibromyalgia Pain
Fibromyalgia leaves you tired and achy, but regular exercise can help reduce fatigue and pain. WebMD shows you exercises you can...
-
Fibromyalgia: 9 Ways to Avoid Fibromyalgia Pain and Fatigue
See how to sleep better, reduce stress, and soothe fibromyalgia muscle pain. WebMD answers questions about alternative therapies,...
Related Disease Conditions
-
Shingles
Shingles, or herpes zoster, is a painful rash caused by the varicella zoster virus. Other shingles symptoms include headache, fever, nausea, and body aches. Treatment focuses on pain management and shortening the duration of the illness with antiviral medications.
-
How Do You Know If You're Having a Fibromyalgia Attack?
What is a fibromyalgia attack, and what can trigger one? Learn the signs of fibromyalgia and some of the treatment options for this condition.
-
Peripheral Neuropathy
Peripheral neuropathy occurs when peripheral nerves become damaged. Peripheral neuropathy causes include diabetes, shingles, vitamin deficiency, and alcohol use. Learn about the four types of peripheral neuropathy.
-
Pain Management
The goal of pain management for each patient is to minimize suffering and improve quality of life. This goal may be different depending on the patient’s circumstances and disease or injury.
-
Fibromyalgia
Fibromyalgia is a chronic condition that causes body-wide muscle pain. Fibromyalgia is characterized by symptoms such as fatigue, sleep disturbances, and tender points. Stress reduction, exercise, and medication are the standard treatments for fibromyalgia.
-
What Foods Trigger Fibromyalgia Pain?
Foods that trigger fibromyalgia pain vary from one person to the next. But in general, processed foods, refined carbohydrates, unhealthy fats and red meats can worsen your symptoms.
-
Occipital Neuralgia (Headache)
Occipital neuralgia is a type of headache that involves inflammation or irritation of occipital nerves. Signs and symptoms include a stabbing and throbbing head pain, and an aching pain in the upper back of the head and neck. Potential causes include infection, irritation, or trauma of the occipital nerves. This type of headache is diagnosed by physical examination findings and imaging tests. Treatment involves a multidisciplinary approach that includes massage, rest, physical therapy, heat, muscle relaxants, and anti-inflammatory drugs. Invasive procedures and even surgery may be considered if first-line treatments fail to bring relief from the chronic pain of this type of headache.
-
Pinched Nerve
A pinched nerve causes pain, numbness, or tingling in the affected area due to pressure on a nerve. Sciatica is an example of a condition caused by a pinched nerve.
-
What Is the Difference Between a Seizure and a Convulsion?
Learn what the main difference between a seizure and a convulsion is, and how to recognize and treat either condition.
-
What Are the Newest Treatments for Fibromyalgia?
Although large-scale studies are still needed to confirm their effectiveness, the newest FDA-approved treatments for fibromyalgia include Quell and milnacipran.
-
What Foods Are Good for Fibromyalgia?
If you suffer from fibromyalgia, eating a diet of fruits, vegetables and lean proteins that are rich in nutrients can boost your overall health and help you manage your symptoms.
-
The Most Severe Symptoms of Fibromyalgia
The pain from fibromyalgia can be intense and constant. It can be severe enough to keep you home from work and other activities.
-
Seizures: Symptoms and Types
Seizures occur when there is an abnormal burst of electrical activity in the brain and are divided into two categories: generalized and partial. Learn about the symptoms of different types of seizures, and check out the center below for more medical references on seizures, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
-
What Is Diabetic Neuropathy?
Diabetic neuropathy a condition in which nerve damage has occurred as a complication of diabetes. The pain from the nerve damage can be severe with tingling or numbness in the part of the body affected. Diabetic neuropathy can occur anywhere in the body. Diabetic neuropathy can cause symptoms like intense pain, numbness, burning, or tingling in the part of the body affected by the condition. There are four types of neuropathy include peripheral, autonomic, proximal and focal. Natural therapies and medications may help relieve the pain and other symptoms of diabetic neuropathy.
-
Migraines and Seizures
Migraines are a type of headache and seizures are the main symptom of epilepsy. Migraine headaches and seizures are two different neurological problems that have similar signs, symptoms, and auras, for example, sensitivity to light (photophobia) and sound, irritability, nausea, and vomiting. Symptoms unique to migraine and migraine auras are water retention, problems sleeping, appetite changes, and talkativeness. Symptoms unique to seizure and seizures auras are depression, a feeling of heaviness, a feeling that a seizure is approaching, and depression. Many of the symptoms of migraine and seizures are the same, however, seizures do not cause migraines; however, people who have seizures are twice as likely to have migraines and vice-versa. People who have migraines are twice as likely to have seizures, and people with seizures are twice as likely to have migraines; however, one condition does not cause the other.
-
Trigeminal Neuralgia
Pain that originates in the face is referred to as trigeminal neuralgia. This pain may be caused by: an injury, an infection in the face, a nerve disorder, or it can occur for no known reason. Trigeminal neuralgia can be treated with antiseizure medications. Some antidepressant drugs also have significant pain relieving effects.
-
Lumbar Spinal Stenosis
Lumbar spinal stenosis can be caused by degenerative arthritis, tumor, infection, or metabolic disorders. Symptoms include low back pain, weakness, pain, numbness, and loss of sensation in the legs. Other conditions may cause similar symptoms of lumbar stenosis, including diabetic neuropathy, claudication, and peripheral vascular disease.
-
Postherpetic Neuralgia
Postherpetic neuralgia (PHN) is a painful complication of shingles. Symptoms include severe pain, itchy skin, and possible weakness or paralysis of the area. There is no treatment for postherpetic neuralgia that is effective for all patients.
-
Neuropathic Pain (Nerve Pain)
Neuropathic pain is a chronic condition that leads to ongoing pain symptoms. Patients can be predisposed to developing neuropathic pain who have conditions such as diabetes, cancer, stroke, HIV, vitamin deficiencies, shingles, and multiple sclerosis. Patient history and nerve testing are used to diagnose neuropathic pain. Antidepressants, antiseizure medications, and other types of medications are used to treat neuropathic pain. Many people with neuropathic pain are able to attain some level of relief.
-
Rheumatoid Arthritis vs. Fibromyalgia
Though rheumatoid arthritis (RA) and fibromyalgia have similar symptoms, RA is an autoimmune disease and fibromyalgia is a chronic pain syndrome. RA symptoms include joint redness, swelling, and pain that lasts more than 6 weeks. Fibromyalgia symptoms include widespread pain, tingling feet or hands, depression, and bowel irritability. Home remedies for both include stress reduction, exercise, and getting enough sleep.
-
What Causes Myoclonic Seizures in Babies?
Epileptic syndromes that cause myoclonic seizures usually begin in early childhood, and last throughout life, though milder forms may improve with adulthood. Doose syndrome (myoclonic-atonic epilepsy), Dravet syndrome (severe myoclonic epilepsy of infancy [SMEI]) and Lennox-Gastaut syndrome are all childhood epilepsy syndromes that may cause seizures in babies and toddlers.
-
Seizure vs. Seizure Disorders: What's the Difference?
Seizures and seizure disorders are not the same medical problems. A seizure happens when the electrical activity in the brain is uncontrolled. There are about 40 different types of seizure disorders, in which epilepsy is one. Symptoms depend on the type of disorder, but can include loss of consciousness, uncontrolled twitching or shaking of one side, or the entire body.
-
What Causes Neuropathy?
Neuropathy is the damage or dysfunction of the nerves. Nerves are the fibers that transmit sensations to the brain or spinal cord. Any nerve damage results in tingling, weakness of the muscle it is connected to, and numbness and pain in the affected area.
-
Can the Vagus Nerve Cause Seizures?
The vagus nerve is an important pathway to the brain in addition to helping to control seizures. Stimulation of the vagus nerve leads to the discharge of electrical energy into a wide area of the brain, disturbing the abnormal brain activity that causes seizures. The vagus nerve is used to treat seizures that do not respond to medications.
-
Can People With Fibromyalgia Live Normal Lives?
People with fibromyalgia can live a normal and active life if they have the support of a physician.
-
Is There a Cure for Neuropathy in the Legs?
There is no cure for peripheral neuropathy. Some cases may improve with rigorous blood sugar control and insulin or with dialysis or renal transplantation.
-
What Is a Cluster Seizure?
Cluster seizures are episodes of increased seizure activity in which two or more seizures occur in 24 hours. Multiple seizures occur one after the other typically with a recovery period between each seizure and are different from a person’s usual seizure pattern.
-
Epilepsy and Seizures: How to Treat?
A seizure is a sudden, uncontrolled electrical disturbance in the brain. Epilepsy is a neurological disorder where brain activities are abnormal, causing more than one or recurrent episodes of seizures. Most cases of seizures can be managed conservatively with medication and supportive treatments.
-
Pain Management: Neuropathic Pain
Neuropathic pain is chronic pain resulting from injury to the nervous system. The injury can be to the central nervous system (brain and spinal cord) or the peripheral nervous system (nerves outside the brain and spinal cord).
Treatment & Diagnosis
- Fibromyalgia FAQs
- Chronic Fatigue FAQs
- Epilepsy and Seizures FAQs
- Pain FAQs
- Diabetic Neuropathy FAQs
- Seizures: When the Computer Goes Haywire
- Medication Disposal
- Does Lupus Cause Seizures?
- Can Paxil Treat Fibromyalgia Pain?
- Sciatica Pain Vs. Fibromyalgia Pain: What Are The Differences?
- Does the Rebuilder Treatment System Treat Nerve Pain (Neuropathy)?
- How Do I Treat Fibromyalgia Pain?
- What Are the Best Shoes for Diabetic Neuropathy in Feet?
- Can Chemotherapy Cause Diabetic Neuropathy?
- Fibromyalgia: 3 Things to Do
Medications & Supplements
Subscribe to MedicineNet's General Health Newsletter
By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
REFERENCE:
FDA Prescribing Information