What are the uses for bepridil?
Bepridil is prescribed for patients with angina pectoris (heart pain) due to coronary artery disease.
Vascor (bepridil hydrochloride) is indicated for the treatment of chronic stable angina (classic effort-associated angina). Because Vascor (bepridil) has caused serious ventricular arrhythmias, including torsades de pointes type ventricular tachycardia, and the occurrence of cases of agranulocytosis associated with its use (see WARNINGS), it should be reserved for patients who have failed to respond optimally to, or are intolerant of, other anti-anginal medication.
Vascor (bepridil) may be used alone or in combination with beta-blockers and/or nitrates. Controlled clinical studies have shown an added effect when Vascor (bepridil) is administered to patients already receiving propranolol.
Is bepridil available as a generic drug?
No
Do I need a prescription for bepridil?
Yes
What are the side effects of bepridil?
- Bepridil can cause very serious cardiac arrhythmias. The risk is increased in patients with a specific electrocardiographic abnormality called QT prolongation and in patients with low blood concentrations of potassium or magnesium.
- Bepridil also can cause increased or decreased heart rate and other abnormal rhythms.
Other side effects that can occur among patients taking bepridil include:
- flu-like symptoms,
- muscle aches,
- fever,
- nausea,
- vomiting,
- loss of appetite,
- constipation,
- gas,
- stomach ache,
- dry mouth,
- diarrhea,
- headache,
- fatigue,
- nervousness,
- drowsiness,
- dizziness,
- depression,
- inability to sleep,
- blurred vision,
- impotence, and
- reduction in sexual drive.
What is the dosage for bepridil?
Bepridil usually is taken once daily. It can be taken with meals or at bedtime if nausea is a problem.
QUESTION
See AnswerWhich drugs or supplements interact with bepridil?
- Bepridil can reduce the strength with which the heart muscle contracts. Drugs which also have this effect when given together with bepridil could seriously reduce contraction of the heart and possibly precipitate congestive heart failure. Such drugs include quinidine (Quinaglute; Duraquin; Quinidex), procainamide (Procan-SR; Pronestyl), disopyramide (Norpace), flecainide (Tambocor), verapamil (Calan; Isoptin; Covera; Verelan), diltiazem (Cardizem; Tiazac; Dilacor), and all beta-blockers, for example, atenolol (Tenormin).
- Bepridil slows the ability of the heart's muscle to recover electrically and get ready for the next contraction. Other drugs which have the same effect could interact with bepridil, possibly causing serious problems with abnormal heart rhythms and should be used cautiously if at all with bepridil. Such drugs include quinidine (Quinaglute; Duraquin; Quinidex), procainamide (Procan-SR; Pronestyl), disopyramide (Norpace), flecainide (Tambocor), and tricyclic antidepressants, for example, amitriptyline (Elavil, Endep).
- Bepridil may increase levels of digoxin (Lanoxin) in the blood, thereby increasing the risk of digoxin toxicity.
- Diuretics, for example, furosemide (Lasix), bumetanide (Bumex), torsemide Demadex), hydrochlorothiazide (Hydrodiuril), chlorthalidone (Hygroton), metolazone (Zaroxolyn) may cause a reduction in blood potassium concentrations thereby increasing the risk of bepridil-induced abnormal heart rhythms.
Is bepridil safe to take if I'm pregnant or breastfeeding?
- Bepridil crosses the placenta, and therefore should not be used during pregnancy unless the benefit to the mother outweighs the potential but unknown risk to the fetus.
- Bepridil is secreted into breast milk and therefore should not be used by breastfeeding mothers unless benefit to the mother clearly outweighs the potential but unknown risk to the infant.
What else should I know about bepridil?
What preparations of bepridil are available?
Tablets: 200 mg.
How should I keep bepridil stored?
Tablets should be stored at room temperature, 15C to 30 C (59 F to 86 F).
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Summary
Bepridil (Vascor, Bepadin) is a drug prescribed for the treatment of angina pectoris due to coronary artery disease. Bepridil is no longer available in the US. Side effects, drug interactions, dosage, and pregnancy and breastfeeding safety should be reviewed prior to taking this medication.
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Related Disease Conditions
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Chest Pain
Chest pain is a common complaint by a patient in the ER. Causes of chest pain include broken or bruised ribs, pleurisy, pneumothorax, shingles, pneumonia, pulmonary embolism, angina, heart attack, costochondritis, pericarditis, aorta or aortic dissection, and reflux esophagitis. Diagnosis and treatment of chest pain depends upon the cause and clinical presentation of the patient's chest pain.
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How the Heart Works
The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood throughout your body to sustain life. It is a fist-sized muscle that beats (expands and contracts) 100,000 times per day, pumping a total of five or six quarts of blood each minute, or about 2,000 gallons per day.
-
Heart Disease (Coronary Artery Disease)
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to the heart. Heart disease can lead to heart attack. Treatment of heart disease involves control of heart disease risk factors through lifestyle changes, medications, and/or stenting or bypass surgery. Heart disease can be prevented by controlling heart disease risk factors.
-
Angina Symptoms
Classic angina symptoms are described as chest pressure that radiates down the arm, into the neck or jaw and is associated with shortness of breath and sweating. Typical angina symptoms should be made worse with activity and should resolve or get better with rest. Angina may not have any pain and instead may present as shortness of breath with exercise, malaise, fatigue, or weakness.
Treatment & Diagnosis
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Medications & Supplements
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- amlodipine besylate
- diltiazem (Cardizem, Cardizem CD, Cardizem LA, Tiazac, Cartia XT, Diltzac, Dilt-CD, and several oth)
- Calcium Channel Blockers (CCBs)
- nifedipine (Procardia, Adalat, Afeditab)
- verapamil (Calan, Verelan, Verelan PM [Discontinued: Isoptin, Isoptin SR, Covera-HS])
- felodipine (Plendil)
- nicardipine, Cardene, Cardene SR
- nisoldipine (Sular)
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Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
First section is courtesy of the U.S. Food and Drug Administration